CAPMATINIB IS AN EFFECTIVE TREATMENT FOR MET-FUSION DRIVEN PEDIATRIC HIGH-GRADE GLIOMA AND SYNERGIZES WITH RADIOTHERAPY

Capmatinib is an effective treatment for MET-fusion driven pediatric high-grade glioma and synergizes with radiotherapy

JASMINE PEARLS Abstract Background Pediatric-type diffuse high-grade glioma (pHGG) is the most frequent malignant brain tumor in children and can be subclassified into multiple entities.Fusion genes activating the MET receptor tyrosine kinase often occur in infant-type hemispheric glioma (IHG) but also in other pHGG and are associated with devastat

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Estimated health benefits, costs, and cost-effectiveness of eliminating industrial trans-fatty acids in Australia: A modelling study.

Backgroundtrans-fatty acids (TFAs) are a well-known risk factor of ischemic heart disease (IHD).In Australia, the highest TFA intake is concentrated to the most socioeconomically disadvantaged groups.Elimination of industrial TFA (iTFA) from the Australian food supply could result in reduced IHD mortality and morbidity while improving health equity

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